{"id":3696,"date":"2022-01-13T11:58:00","date_gmt":"2022-01-13T04:58:00","guid":{"rendered":"https:\/\/infosite.hitap.net\/?p=3696"},"modified":"2022-03-01T15:19:02","modified_gmt":"2022-03-01T08:19:02","slug":"a-systematic-review-of-methodological-approaches-for-evaluating-real-world-effectiveness-of-covid-19-vaccines-advising-resource-constrained-settings","status":"publish","type":"post","link":"https:\/\/infosite.hitap.net\/en\/a-systematic-review-of-methodological-approaches-for-evaluating-real-world-effectiveness-of-covid-19-vaccines-advising-resource-constrained-settings\/","title":{"rendered":"A systematic review of methodological approaches for evaluating real-world effectiveness of COVID-19 vaccines: Advising resource-constrained settings"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3696\" class=\"elementor elementor-3696\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-63eda89c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"63eda89c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5efdb9ba\" data-id=\"5efdb9ba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2bda52a0 elementor-widget elementor-widget-text-editor\" data-id=\"2bda52a0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.10.0 - 09-01-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><div class=\"post-views content-post post-3696 entry-meta\">\r\n\t\t\t\t<span class=\"post-views-icon dashicons dashicons-welcome-view-site\"><\/span> <span class=\"post-views-label\">\u0e08\u0e33\u0e19\u0e27\u0e19\u0e1c\u0e39\u0e49\u0e40\u0e02\u0e49\u0e32\u0e0a\u0e21:<\/span> <span class=\"post-views-count\">1,130<\/span>\r\n\t\t\t<\/div><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3398ea5e elementor-widget elementor-widget-text-editor\" data-id=\"3398ea5e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Abstract<\/h3><p>Real-world effectiveness studies are important for monitoring performance of COVID-19\u00a0vaccination programmes and informing COVID-19 prevention and control policies. We\u00a0aimed to synthesise methodological approaches used in COVID-19 vaccine effectiveness\u00a0studies, in order to evaluate which approaches are most appropriate to implement in low-and middle-income countries (LMICs). For this rapid systematic review, we searched PubMed and Scopus for articles published from inception to July 7, 2021, without language\u00a0restrictions. We included any type of peer-reviewed observational study measuring COVID-19 vaccine effectiveness, for any population. We excluded randomised control trials and\u00a0modelling studies. All data used in the analysis were extracted from included papers. We used a standardised data extraction form, modified from STrengthening the Reporting of\u00a0OBservational studies in Epidemiology (STROBE). Study quality was assessed using the\u00a0REal Life EVidence AssessmeNt Tool (RELEVANT) tool. This study is registered with\u00a0PROSPERO, CRD42021264658. Our search identified 3,327 studies, of which 42 were eligible for analysis. Most studies (97.5%) were conducted in high-income countries and the\u00a0majority assessed mRNA vaccines (78% mRNA only, 17% mRNA and viral vector, 2.5%\u00a0viral vector, 2.5% inactivated vaccine). Thirty-five of the studies (83%) used a cohort study\u00a0design. Across studies, short follow-up time and limited assessment and mitigation of potential confounders, including previous SARS-CoV-2 infection and healthcare seeking behaviour, were major limitations. This review summarises methodological approaches for\u00a0evaluating real-world effectiveness of COVID-19 vaccines and highlights the lack of such\u00a0studies in LMICs, as well as the importance of context-specific vaccine effectiveness data.\u00a0Further research in LMICs will refine guidance for conducting real-world COVID-19 vaccine\u00a0effectiveness studies in resource-constrained settings.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc739e6 elementor-align-justify elementor-widget elementor-widget-button\" data-id=\"6dc739e6\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930.pdf\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Click here to download<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-138af2ea elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"138af2ea\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-57c868c1\" data-id=\"57c868c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27ff604c elementor-widget elementor-widget-image\" data-id=\"27ff604c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.10.0 - 09-01-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.hitap.net\/wp-content\/uploads\/2020\/12\/prioritizing_criticalcare_resources_in_response_to_covid19_lessons_from_the_development_of_thailands_triage_protocol.pdf\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1700\" height=\"2200\" src=\"https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01.jpg\" class=\"attachment-full size-full wp-image-3701\" alt=\"\" srcset=\"https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01.jpg 1700w, https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01-232x300.jpg 232w, https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01-791x1024.jpg 791w, https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01-768x994.jpg 768w, https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01-1187x1536.jpg 1187w, https:\/\/infosite.hitap.net\/wp-content\/uploads\/2022\/03\/journal.pone_.0261930_Page_01-1583x2048.jpg 1583w\" sizes=\"auto, (max-width: 1700px) 100vw, 1700px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Abstract Real-world effectiveness studies are important for monitoring performance of COVID-19&nbsp;vaccination programmes and informing COVID-19 prevention and control policies. We&nbsp;aimed to synthesise methodological approaches used in COVID-19 vaccine effectiveness&nbsp;studies, in order to evaluate which approaches are most appropriate to implement in low-and middle-income countries (LMICs). For this rapid systematic review, we searched PubMed and Scopus [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3697,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[72],"tags":[],"class_list":["post-3696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-international-publications-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/posts\/3696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/comments?post=3696"}],"version-history":[{"count":6,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/posts\/3696\/revisions"}],"predecessor-version":[{"id":3730,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/posts\/3696\/revisions\/3730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/media\/3697"}],"wp:attachment":[{"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/media?parent=3696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/categories?post=3696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infosite.hitap.net\/en\/wp-json\/wp\/v2\/tags?post=3696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}